A long-standing medical mystery from 1972 has finally been solved by British researchers who identified a completely new blood group called MAL. This discovery emerged from studying the blood of a pregnant woman who lacked the AnWj antigen, which is present in over 99.9% of the population.

Key Findings:
Genetic Origin: Research published in 2024 revealed that this rare blood group results from a mutation in the MAL gene.
Clinical Importance: Dr. Louise Tilly praised the breakthrough as a culmination of extensive efforts, enhancing care for patients with this rare condition.
Significance of the Discovery:
Blood Compatibility: Understanding blood groups is essential as mismatched antigens during transfusions can lead to severe, sometimes fatal reactions.
Disease Diagnosis: With the genetic marker identified, physicians can determine if an individual's MAL-negative blood type is inherited or the result of an underlying illness, potentially signaling other medical issues.
Role of MAL Protein:
Despite its small size, the MAL protein plays a crucial role in maintaining cellular membrane stability, underscoring its importance in overall cellular function.